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Piperacillin and Tazobactam for Injection is a combination product consisting of a penicillin-class antibacterial, piperacillin, and a Î²-lactamase inhibitor, tazobactam, indicated for the treatment of patients with moderate to severe infections caused by susceptible isolates of the designated bacteria in the conditions listed below.
1.1 Intra-abdominal Infections
Appendicitis (complicated by rupture or abscess) and peritonitis caused by Î²-lactamase producing isolates of Escherichia coli or the following members of the Bacteroides fragilis group: B. fragilis, B. ovatus, B. thetaiotaomicron, or B. vulgatus. The individual members of this group were studied in fewer than 10 cases.
1.2 Skin and Skin Structure Infections
Uncomplicated and complicated skin and skin structure infections, including cellulitis, cutaneous abscesses and ischemic/diabetic foot infections caused by Î²-lactamase producing isolates of Staphylococcus aureus.
1.3 Female Pelvic Infections
Postpartum endometritis or pelvic inflammatory disease caused by Î²-lactamase producing isolates of Escherichia coli.
1.4 Community-acquired Pneumonia
Community-acquired pneumonia (moderate severity only) caused by Î²-lactamase producing isolates of Haemophilus influenzae.
1.5 Nosocomial Pneumonia
Nosocomial pneumonia (moderate to severe) caused by Î²-lactamase producing isolates of Staphylococcus aureus and by piperacillin/tazobactam-susceptible Acinetobacter baumannii, Haemophilus influenzae, Klebsiella pneumoniae, and Pseudomonas aeruginosa (Nosocomial pneumonia caused by P. aeruginosa should be treated in combination with an aminoglycoside) [see Dosage and Administration ( 2) ].